By A. F. Junod (auth.), Dr. J. L. Vincent (eds.)
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Extra resources for 6th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, April 15–18, 1986
It is clear that increases in intracranial pressures can be seen as a consequence of cerebral hypoxia, but it is not clear that any specific therapy can be directed at these changes in pressure. Therefore, for the majority of patients with acute respiratory failure monitoring of these physiologic parameters has not been useful . The fact remains that maintenance of cardiac output and organ perfusion is of critical importance to eventual out- 36 P. G. Boysen come. The spectrum of changes in cardiac output and regional perfusion would indicate that maintenance of arterial oxygen saturation is of prime importance.
Clinically the entire spectrum of change in carbon dioxide is evident and normocarbia, hypercarbia, or hypocarbia may occur depending on the volume of the aspirate and the underlying pulmonary status. Secondly, there is a severe physiologic shunt related to the ventilation-perfusion abnormalities. Cardiac output will change and can be divided into acute changes and changes seen during therapy. In every case cardiac output decreases dramatically and significantly. With resuscitation and the restoration of adequate oxygenation there is usually some improvement in cardiac output but increasingly clinicians have chosen to monitor cardiac output as a separate parameter especially since therapy with raised airway pressure may also have an effect on cardiac output.
3] showed a close relationship between increased lung water and the albumin leak index when lung injury and oedema was induced by thiourea. They found no change in leak index in hydrostatic lung oedema. Basran et al.  found the leak index to be abnormal in all ten of their patients with ARDS. In the second method a small molecular weight tracer solute is introduced directly into the airspaces either in a small volume of saline or as an aerosol. 20 J. G. Jones Measurement of the clearance rate from lung into blood is achieved either with the aid of the gamma camera or scintillation probes .
6th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, April 15–18, 1986 by A. F. Junod (auth.), Dr. J. L. Vincent (eds.)